Through focusing on Sertoli cells, the CoRNuSperm project proposes to characterize yet unidentified signaling pathways acting to control these pathophysiological processes, collectively named spermatogenesis CoRegulators of Nuclear receptor in Spermatogenesis.
To this aim, CoRNuSperm project proposes to uncover the biological functions and the molecular mechanisms of NCoA and NCoR in Sertoli cells through a combination of genetic, molecular and pharmacological approaches both in vivo mutant mice and in vitro Sertoli cells in culture. The present proposal is to be developed by a young researcher working within an established research group that studies the physiological role played by retinoic acid in tissue homeostasis.
The author of this summary is the project coordinator, who is responsible for the content of this summary.
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They regulate the cellular response to hormones such as sex steroids, vitamin D 3 , adrenal steroids and other metabolic ligands, and are involved in metabolism, development and reproduction.
David Lonard, Ph.D. | People | Houston, Texas
The nuclear receptor superfamily is classified by sequence alignment and phylogenetic tree construction into six main subfamilies:. Of the 48 nuclear receptors in the human genome, 24 are ligand-dependent transcription factors.
The activity of endogenous ligands on nuclear receptors is normally to upregulate gene expression. Upon ligand-binding a conformation change results in the receptor that regulates the recruitment of coregulators and chromatin-modifying machinery.
New Releases. Description This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases.
Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience.
A special emphasis is placed on the "classic" papers as well as perspectives on future directions for the field. Product details Format Hardback pages Dimensions Rating details.
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